VASCULAR BIOLOGY New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
نویسندگان
چکیده
1Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; 2Johns Hopkins University School of Medicine, Baltimore, MD; 3Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; and 4Central Proteomics Facility, Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
منابع مشابه
New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes.
Notch signaling is an evolutionary conserved pathway that is mediated by cell-cell contact. It is involved in a variety of developmental processes and has an essential role in vascular development and angiogenesis. Delta-like 4 (Dll4) is a Notch ligand that is up-regulated during angiogenesis. It is expressed in endothelial cells and regulates the differentiation between tip cells and stalk cel...
متن کاملDll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment
Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Dll4 is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4-containing exosomes from a distance. Howeve...
متن کاملRegulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis.
Notch and its ligands play critical roles in cell fate determination. Expression of Notch and ligand in vascular endothelium and defects in vascular phenotypes of targeted mutants in the Notch pathway have suggested a critical role for Notch signaling in vasculogenesis and angiogenesis. However, the angiogenic signaling that controls Notch and ligand gene expression is unknown. We show here tha...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and it is induced by vascular endothelial growth factor (VEGF)–A and hypoxia. Gene targeting studies have shown that Dll4 is required for normal embryonic vascular remodeling, but the mechanisms underlying Dll4 regulatory functions are current...
متن کاملRhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.
OBJECTIVE Notch signaling has a critical role in vascular development and morphogenesis. Activation of Notch in endothelial cells led to a senescence-like phenotype with loss of barrier function. Our objective was to understand the molecular pathways mediating this phenotype. METHODS AND RESULTS Human primary endothelial cells increase expression of Notch receptors and ligands during propagat...
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تاریخ انتشار 2010